SantaClaraRecruiter Since 2001
the smart solution for Santa Clara jobs

Senior Research Assistant

Company: Stanford Medicine
Location: Santa Clara
Posted on: May 8, 2022

Job Description:

The Petritsch lab broadly investigates underlying causes for the intra-tumoral heterogeneity and immune suppression in brain tumors from a developmental neuro-developmental perspective. Proper cell fate decisions by neuroglia stem cells are critical for growing the cell lineages that form the brain during development and to maintain adult brain homeostasis. The mechanisms for cell fate decisions in the human brain are largely unknown. By using patient-derived cells from brain surgeries, we investigate cell fate decision mechanisms in the normal brain and in brain malignancies. We think that defective cell fate decisions fuel the intra-humoral heterogeneity and plasticity that makes treatment of human brain tumors so challenging. We therefore work to gain an understanding of how brain cells control the fate of their progeny, whereby we unravel novel points of vulnerabilities in brain tumor cells, that could be exploited therapeutically.

We are currently seeking an experienced and dynamic Research Professional to join our group unraveling the role for neuro-glia stem cells in human brain diseases including brain tumors. Our neuroscience-based lab uses a variety of single cell and life imaging techniques, including RNA seq, ATAC seq, live cell imaging, including TIRF, FRAP/FRET. We use methods to analyze neuro-glia stem cell interactions with the brain immune landscape, including mass cytometry and behavioral assays to study long-term neuro-cognitive effects of brain tumor therapies targeting neuro-glia stem cells. The LSRP1 will also manage lab activities and provide general/administrative lab oversight.

Duties include:

  • Independently conduct a portion of the research project(s). Make recommendations on experimental design and/or research direction to principal investigator.
  • Independently conduct complex (lab and/or field) experiments to gather data for a portion of a major research project.
  • Interpret and analyze results, often where few guidelines exist, and make modifications to existing procedures and protocols.
  • Develop new research protocols where appropriate protocols are not described in the literature or where modification or adaptation of standard procedures and protocols is required.
  • Participate in multidisciplinary teams across different faculties or schools.
  • Perform ongoing literature review to remain current with new procedures and related research; apply to ongoing research and development of new protocols.
  • Contribute substantively to the preparation of papers for publication, especially in the results section, and to publication of findings. Present ongoing work to colleagues and/or academic conferences.
  • Oversee supply and equipment budget under supervision of principal investigator or business manager.
  • Work with health and safety department to ensure lab complies with regulations and all required trainings.
  • Supervise (either formally or informally) staff or students as needed, including oversight and direction on techniques, as well as consultation on project work. Serve as a technical resource for other research staff.
  • Oversee the daily activities of the laboratory including lab maintenance; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.
    *- Other duties may also be assigned

    DESIRED QUALIFICATIONS:
    • Minimum 2 years research and/or lab management experience required.
    • Experience with use and maintenance of confocal microscope desirable.
    • Experience working with rodents, including transgenic line breeding and genotyping.
    • Experience with various neurological behavior testing including rotating beam test, cylinder test and staircase test.
    • Experience with rodent stereotaxic surgery such as virus injection and fiber implants.
    • Experience with tissue culture, basic molecular biology and cell biology techniques

      EDUCATION & EXPERIENCE (REQUIRED):

      Bachelor's degree in related scientific field and two years of relevant work experience; or Master's degree in a related scientific field.

      KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
      • Comprehensive understanding of scientific principles.
      • General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
      • Strong analytical skills and excellent judgment.
      • Ability to maintain detailed records of experiments and outcomes.
      • Ability to work under deadlines with general guidance is essential.
      • Excellent organizational skills and demonstrated ability to accurately complete detailed work.

        PHYSICAL REQUIREMENTS*:
        • Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
        • Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
        • Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
        • Must have correctible vision to perform duties of the job.
        • Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
        • Ability to lift heavy objects weighing up to 50 pounds.
        • Ability to work in a dusty, dirty, and odorous environment.
        • Position may require repetitive motion.
          *- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

          WORKING CONDITIONS:
          • May require working in close proximity to blood borne pathogens.
          • May require work in an environment where animals are used for teaching and research.
          • Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
          • Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
          • May require extended or unusual work hours based on research requirements and business needs.

            WORK STANDARDS:
            • Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
            • Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors bases on training and lessons learned.
            • Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu .

              As an organization that receives federal funding, Stanford University has a COVID-19 vaccination requirement that will apply to all university employees, including those working remotely in the United States and applicable subcontractors. To learn more about COVID policies and guidelines for Stanford University Staff, please visit https://cardinalatwork.stanford.edu/working-stanford/covid-19/interim-policies/covid-19-surveillance-testing-policy

              Additional Information
              • Schedule: Full-time
              • Job Code: 4952
              • Employee Status: Regular
              • Pay Grade: G
              • Department URL: http://neurosurgery.stanford.edu
              • Requisition ID: 93807 As an organization that receives federal funding, Stanford University has a COVID-19 vaccination requirement that will apply to all university employees, including those working remotely in the United States and applicable subcontractors. To learn more about COVID policies and guidelines for Stanford University Staff, please visit https://cardinalatwork.stanford.edu/working-stanford/covid-19/interim-policies/covid-19-surveillance-testing-policy

Keywords: Stanford Medicine, Santa Clara , Senior Research Assistant, Other , Santa Clara, California

Click here to apply!

Didn't find what you're looking for? Search again!

I'm looking for
in category
within


Log In or Create An Account

Get the latest California jobs by following @recnetCA on Twitter!

Santa Clara RSS job feeds