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Cryo EM Specialist

Company: Stanford Medicine
Location: Santa Clara
Posted on: November 26, 2022

Job Description:

Our Purpose
Stanford Medicine is leading the biomedical revolution in precision health. We are transforming health care away from after-the-fact diagnosis to prediction and prevention and away from one-size-fits-all medicine to personalized care that empowers people to lead healthy lives. We are leveraging the art and science of medicine to predict and prevent disease before it strikes and cure it decisively if it does.

To achieve our Precision Health vision, we are integrating, building, and leveraging our strengths in fundamental research, the new field of biomedical data science, and nine transformative biomedical platforms. As a learning health system, we will apply these advances in our hospitals and health care delivery systems within Stanford Health Care and Stanford Children's Health.

Our Values
Fulfilling our promise to humanity requires the engagement of a diverse, creative, and collaborative team of professionals who work together to advance our research, education, and patient care mission. We strive to create a culture of inclusion and belonging to ensure all employees have the meaningful employment experience that is necessary to do their best work. We value and integrate justice, equity, diversity, and inclusion into all that we do, as reflected by the following initiatives:

o Stanford Medicine diversity website:
o Stanford Medicine Commission on Justice and Equity:
o Leader's Pledge to anti-racism:
o REACH Initiative:
o Staff IDEAL initiative:
o SoM staff JEDI efforts:

Our Work
The Office of the Senior Associate Dean for Research develops policies and practices to advance rigorous and transformational research at the School of Medicine. Serving as a resource and providing support services for researchers to advance cutting edge ideas, the Research Office aims to accelerate discovery and amplify the impact of Stanford innovation to lead the biomedical revolution in Precision Health.
Stanford School of Medicine is seeking a cryo-EM scientist (Life Science Research Professional 2) to support and train users in cryo electron microscopy service (cryoEM center or cEMc), and independently conduct a portion of research projects as well as support the operation of our expanding, state-of-the-art electron microscopy facility. The cEMc includes 2 Titan Krios and 1 Glacios microscope for single particle and tomography studies, as well as a newly installed Aquilos2 FIB-SEM. The facility will be staffed by 2-3 team members. This team member, along with others, will be responsible for oversight and maintenance of these microscopes as well as training and assisting users. The cryo-EM specialist will have ample opportunities to advance and grow professionally within our research environment, which includes the scientific communities at both Stanford and SLAC.

Duties include:

--- Independently conduct portions of research projects. Make recommendations on experimental design and/or research direction to principal investigator.
--- Independently conduct complex (lab and/or field) experiments to gather data for a portion of a major research project.
--- Interpret and analyze results, often where few guidelines exist, and make modifications to existing procedures and protocols.
--- Load samples and tune microscopes prior to data collection.
--- Train and oversee users for data collection.
--- Evaluate quality of data obtained by users.
--- Interface and collaborate with High Performance Computing team, who will assist with computational needs for optimal data collection, storage, and data processing.
--- Interface and collaborate with Microscopy Core, which houses electron microscopes for preliminary screening of samples.
--- Implement data collection strategies that will benefit our user community.
--- Maintain accurate logs for microscope performance and usage.
--- Develop new research protocols where appropriate protocols are not described in the literature or where modification or adaptation of standard procedures and protocols is required.
--- Participate in multidisciplinary teams across different faculties or schools.
--- Perform ongoing literature review to remain current with new procedures and related research; apply to ongoing research and development of new protocols.
--- Contribute substantively to the preparation of papers for publication, especially in the results section, and to publication of findings. Present ongoing work to colleagues and/or academic conferences.
--- Oversee supply and equipment budget under supervision of principal investigator or business manager.
--- Work with the health and safety department to ensure lab complies with regulations and all required trainings.
--- Supervise (either formally or informally) staff or students as needed, including oversight and direction on techniques, as well as consultation on project work. Serve as a technical resource for other research staff.
--- Oversee the daily activities of the laboratory including lab maintenance, maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.

- Other duties may also be assigned

DESIRED QUALIFICATIONS:
--- PhD or M.S. in Biology, Molecular Biology, Biochemistry, Structural Biology, Bioengineering, or related field.
--- Experience with Cryo-microscopy (cryo-EM) specimen preparation, data collection, and structure determination, in particular cryoFIB-SEM and associated techniques.
--- 2-3 years of cryo-EM experience, with expertise in handling samples, using microscopes, and evaluating data.
--- Solid understanding of the principles of transmission electron microscopy.
--- Familiarity with computational image processing and analysis of cryo-EM images.
--- General understanding of single particle cryo-EM workflow; experience in cryo electron tomography desired.
--- Excellent communication and interpersonal skills.

EDUCATION & EXPERIENCE (REQUIRED): Bachelor's degree in related scientific field and two years of relevant work experience; or Master's degree in a related scientific field.

KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):

--- Comprehensive understanding of scientific principles.
--- General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
--- Strong analytical skills and excellent judgment.
--- Ability to maintain detailed records of experiments and outcomes.
--- Ability to work under deadlines with general guidance is essential.
--- Excellent organizational skills and demonstrated ability to accurately complete detailed work.

PHYSICAL REQUIREMENTS :
--- Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
--- Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
--- Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
--- Must have correctible vision to perform duties of the job.
--- Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
--- Ability to lift heavy objects weighing up to 50 pounds.
--- Ability to work in a dusty, dirty, and odorous environment.
--- Position may require repetitive motion.

- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

WORKING CONDITIONS:

--- May require working in close proximity to blood borne pathogens.
--- May require work in an environment where animals are used for teaching and research.
--- Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
--- Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
--- May require extended or unusual work hours based on research requirements and business needs.

WORK STANDARDS (from JDL):
--- Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
--- Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors bases on training and lessons learned.
--- Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, .

As an organization that receives federal funding, Stanford University has a COVID-19 vaccination requirement that will apply to all university employees, including those working remotely in the United States and applicable subcontractors. To learn more about COVID policies and guidelines visit:

OUR BENEFITS:

--- Market Competitive Compensation: We offer a competitive salary that is commensurate with your relevant work experience. . click apply for full job details

Keywords: Stanford Medicine, Santa Clara , Cryo EM Specialist, Other , Santa Clara, California

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