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Principal System Engineer

Company: Disability Solutions
Location: Santa Clara
Posted on: September 16, 2023

Job Description:

The PositionWe are looking for a passionate Principal System Engineer to join our Systems Development Group to support the Next Generation Sequencing (NGS) products, with a strong focus on the automation of the NGS process and data analysis. You will be a hands-on key contributor in feasibility, development testing and integration phases of end-to-end NGS solutions, according to customer & product requirements, applicable regulatory and quality standards. Responsibilities:This position is responsible for, but not limited to, the following:

  • Perform systems development activities as part of the project team to develop new NGS solutions and ensure the product design meets customer needs as well as applicable regulations or standards. May serve as the Systems representative on cross-functional teams and efforts.
  • Participate in developing and managing a large subsystem-level or system level product requirements, critical parameter management (CPM) & configuration management and traceability analysis.
  • Develop, execute and document test cases for verification and validation. Ensure complete and comprehensive coverage of requirements in the test campaign.
  • Plan and prioritize activities /assignments to guide junior team members.
  • Perform systems integration and testing activities to verify system performance through simulation, test, and measurements. Assess results for applicability, validity, and conformance to product requirements.
  • Work independently with general management direction to drive product development and collaborations to identify opportunities for continuous improvement.
  • Perform product risk management activities using tools such as Hazard Analysis or Failure Modes and Effects Analysis (FMEA) according to Roche's applicable regulatory and quality standards and provide risk mitigation recommendations to the project team.
  • Collaborate with project teams and internal/external stakeholders to create project artifacts and maintain related documents in Design history files.
  • Keep supervisor/project leader informed of project status, particularly of significant findings and results in critical problem areas.
  • Perform work according to established internal safety guidelines and procedures, and as specified by appropriate external regulatory agencies (e.g. OSHA).
  • Maintain compliance as required by regulatory bodies and the company's quality system.Who you are You're someone who wants to influence your own development. You're looking for a company where you have the opportunity to pursue your interests across functions and geographies.Where a job title is not considered the final definition of who you are, but the starting point.Qualifications:
    • Bachelor's degree in Systems Engineering, Biomedical Engineering, Electrical Engineering, Software Engineering, or related disciplines. Advanced degree preferred.
    • Required BS or equivalent with 8+ years related experience or MS with 5+ years related experience; preferred MS with 6+ years related experience. BS with 5 years' experience or MS with 3+ year end-to-end NGS application development experience is encouraged to apply but could be subject to a level re-calibration.
    • Strong data analysis skills using standard analysis software (e.g. with JMP) and able to determine how best to represent it visually to managers and stakeholders.
    • Hands-on development experience of at least one of the programming languages such as Python, R, and Java for hardware automation or statistics analysis applications.
    • Knowledge of all phases of DNA sequencing domain knowledge is highly desirable.
    • Experience with systems reliability is highly desirable.
    • Hand-on troubleshooting experience with automated systems is highly desirable.
    • Experience using automated (SW) testing tools to drive systems integration is desirable.
    • Experience with cloud deployment is desirable.
    • Strong analytical, problem solving, communication, and interpersonal skills and fast learner.Relocation benefits are not offered for this position. The expected salary range for this position based on the primary location of Santa Clara, CA is $120,500 and $152,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed here:Who we areAt Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.If you have a disability and need an accommodation in connection with the on-line application process, please email us at

Keywords: Disability Solutions, Santa Clara , Principal System Engineer, Other , Santa Clara, California

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