Senior Research Associate II, Medicinal Chemistry
Company: Maze Therapeutics
Location: South San Francisco
Posted on: January 1, 2026
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Job Description:
The Position Join our innovative drug discovery team as a Senior
Research Associate II. In this role, you’ll apply your expertise in
organic and medicinal chemistry to synthesize, purify, and
characterize novel molecules that could lead to breakthrough
therapies. You’ll work hands-on with cutting-edge techniques and
collaborate across functions to advance our research programs. The
Impact You’ll Have Execute multistep syntheses of complex small
molecules and characterize intermediates and final products.
Propose new compounds for synthesis based on SAR and synthetic
knowledge. Summarize and interpret results and present findings in
research meetings. Learn new laboratory techniques, troubleshoot
experiments, and ensure high-quality execution. Utilize scientific
literature and databases (e.g., SciFinder) to design efficient
synthetic routes. Collaborate with scientists across functions to
develop and optimize newly generated molecules. What We’re Looking
For B.S./M.S. in Chemistry with at least 4 years of relevant
experience in synthetic organic or medicinal chemistry.
Demonstrated experience in organic synthesis, chromatographic
purification, and compound characterization using modern analytical
techniques (NMR, LCMS, HPLC, etc.). Strong organizational skills
and attention to detail. A proactive, solution-oriented approach
and commitment to collaboration. Ability to learn and adapt in a
fast-paced environment. Excellent verbal and written communication
skills. About Maze Therapeutics Maze Therapeutics is a
clinical-stage biopharmaceutical company harnessing the power of
human genetics to develop novel, small molecule precision medicines
for patients living with renal, cardiovascular and related
metabolic diseases, including obesity. The company is advancing a
pipeline using its Compass platform, which allows it to identify
and characterize genetic variants in disease and then link those
variants to the biological pathways that drive disease in specific
patient groups through a process it refers to as variant
functionalization. The company’s pipeline is led by two wholly
owned lead programs, MZE829 and MZE782, each of which represents a
novel precision medicine-based approach for chronic kidney disease.
Maze is based in South San Francisco. Our People Maze is comprised
of a team of passionate and creative professionals committed to
discovering and delivering transformative medicines to patients
suffering from both rare and common genetic diseases. We are
fostering a culture that encourages vision, initiative and the
development of talent. Our supportive work environment inspires
creative thinking and freedom of expression, resulting in a
stimulating atmosphere where people enjoy coming to work. While we
have a passion for advanced science and pride ourselves on
excellence in execution, ultimately, everything we do is about
patients. Our Core Values Further Together – Our path is paved with
challenges, but with resilience and a team-first mentality, we’ll
achieve our mission. Impact Obsessed – We embrace the bold, take
calculated risks, and learn from our mistakes to improve the lives
of others. Stand True – Our integrity is foundational; it guides us
no matter the obstacle. The expected annual salary range for
employees located in the San Francisco Bay Area is $120,000 -
$147,000. Additionally, this position is eligible for an annual
performance bonus. Maze performs position-based compensation
benchmarking to industry market data to ensure we pay competitive
wages. Determination of starting salary will depend upon a variety
of job-related factors, which may include professional experience,
skills, and job location. The expected salary range for this role
may be modified in the future. Maze offers a robust benefits
package to our eligible employees including competitive medical,
dental, and vision insurance, mental health offerings, equity
incentive plan, 401(k) program with employer match and a generous
holiday and PTO policy. LI-Hybrid
Keywords: Maze Therapeutics, Santa Clara , Senior Research Associate II, Medicinal Chemistry, Science, Research & Development , South San Francisco, California
